Ab Initio Liquid Hydrogen Muon Cooling Simulations with ELMS in ICOOL

This paper presents new theoretical results on the passage of muons through liquid hydrogen which have been confirmed in a recent experiment. These are used to demonstrate that muon bunches may be compressed by ionisation cooling more effectively than suggested by previous calculations. Muon cooling depends on the differential cross section for energy loss and scattering of muons. We have calculated this cross section for liquid H2 from first principles and atomic data, avoiding traditional assumptions. Thence, 2-D probability maps of energy loss and scattering in mm-scale thicknesses are derived by folding, and stored in a database. Large first-order correlations between energy loss and scattering are found for H2, which are absent in other simulations. This code is named ELMS, Energy Loss & Multiple Scattering. Single particle trajectories may then be tracked by Monte Carlo sampling from this database on a scale of 1 mm or less. This processor has been inserted into the cooling code ICOOL. Significant improvements in 6-D muon cooling are predicted compared with previous predictions based on GEANT. This is examined in various geometries. The large correlation effect is found to have only a small effect on cooling. The experimental scattering observed for liquid H2 in the MUSCAT experiment has recently been reported to be in good agreement with the ELMS prediction, but in poor agreement with GEANT simulation.Comment: 6 pages, 3 figure

Using 21-cm absorption surveys to measure the average HI spin temperature in distant galaxies

We present a statistical method for measuring the average HI spin temperature in distant galaxies using the expected detection yields from future wide-field 21cm absorption surveys. As a demonstrative case study we consider a simulated all-southern-sky survey of 2-h per pointing with the Australian Square Kilometre Array Pathfinder for intervening HI absorbers at intermediate cosmological redshifts between $z = 0.4$ and $1$. For example, if such a survey yielded $1000$ absorbers we would infer a harmonic-mean spin temperature of $\overline{T}_\mathrm{spin} \sim 100$K for the population of damped Lyman $\alpha$ (DLAs) absorbers at these redshifts, indicating that more than $50$ per cent of the neutral gas in these systems is in a cold neutral medium (CNM). Conversely, a lower yield of only 100 detections would imply $\overline{T}_\mathrm{spin} \sim 1000$K and a CNM fraction less than $10$ per cent. We propose that this method can be used to provide independent verification of the spin temperature evolution reported in recent 21cm surveys of known DLAs at high redshift and for measuring the spin temperature at intermediate redshifts below $z \approx 1.7$, where the Lyman-$\alpha$ line is inaccessible using ground-based observatories. Increasingly more sensitive and larger surveys with the Square Kilometre Array should provide stronger statistical constraints on the average spin temperature. However, these will ultimately be limited by the accuracy to which we can determine the HI column density frequency distribution, the covering factor and the redshift distribution of the background radio source population.Comment: 11 pages, 9 figures, 1 table. Proof corrected versio

Observations and models for needle-tissue interactions

The asymmetry of a bevel-tip needle results in the needle naturally bending when it is inserted into soft tissue. In this study we present a mechanics-based model that calculates the deflection of the needle embedded in an elastic medium. Microscopic observations for several needle- gel interactions were used to characterize the interactions at the bevel tip and along the needle shaft. The model design was guided by microscopic observations of several needle- gel interactions. The energy-based model formulation incor- porates tissue-specific parameters such as rupture toughness, nonlinear material elasticity, and interaction stiffness, and needle geometric and material properties. Simulation results follow similar trends (deflection and radius of curvature) to those observed in macroscopic experimental studies of a robot- driven needle interacting with different kinds of gels. These results contribute to a mechanics-based model of robotic needle steering, extending previous work on kinematic models

Role of a plausible nuisance contributor in the declining obesity-mortality risks over time.

CONTEXT: Recent analyses of epidemiological data including the National Health and Nutrition Examination Survey (NHANES) have suggested that the harmful effects of obesity may have decreased over calendar time. The shifting BMI distribution over time coupled with the application of fixed broad BMI categories in these analyses could be a plausible nuisance contributor to this observed change in the obesity-associated mortality over calendar time. OBJECTIVE: To evaluate the extent to which observed temporal changes in the obesity-mortality association may be due to a shifting population distribution for body mass index (BMI), coupled with analyses based on static, broad BMI categories. DESIGN, SETTING, AND PARTICIPANTS: Simulations were conducted using data from NHANES I and III linked with mortality data. Data from NHANES I were used to fit a true model treating BMI as a continuous variable. Coefficients estimated from this model were used to simulate mortality for participants in NHANES III. Hence, the population-level association between BMI and mortality in NHANES III was fixed to be identical to the association estimated in NHANES I. Hazard ratios (HRs) for obesity categories based on BMI for NHANES III with simulated mortality data were compared to the corresponding estimated HRs from NHANES I. MAIN OUTCOME MEASURES: Change in hazard ratios for simulated data in NHANES III compared to observed estimates from NHANES I. RESULTS: On average, hazard ratios for NHANES III based on simulated mortality data were 29.3% lower than the estimates from NHANES I using observed mortality follow-up. This reduction accounted for roughly three-fourths of the apparent decrease in the obesity-mortality association observed in a previous analysis of these data. CONCLUSIONS: Some of the apparent diminution of the association between obesity and mortality may be an artifact of treating BMI as a categorical variable

Reconstruction of deglacial sea surface temperatures in the tropical Pacific from selective analysis of a fossil coral

The Sr/Ca of coral skeletons demonstrates potential as an indicator of sea surface temperatures (SSTs). However, the glacial-interglacial SST ranges predicted from Sr/Ca of fossil corals are usually higher than from other marine proxies. We observed infilling of secondary aragonite, characterised by high Sr/Ca ratios, along intraskeletal pores of a fossil coral from Papua New Guinea that grew during the penultimate deglaciation (130 +/- 2 ka). Selective microanalysis of unaltered areas of the fossil coral indicates that SSTs at similar to 130 ka were &lt;= 1 degrees C cooler than at present in contrast with bulk measurements ( combining infilled and unaltered areas) which indicate a difference of 6-7 degrees C. The analysis of unaltered areas of fossil skeletons by microprobe techniques may offer a route to more accurate reconstruction of past SSTs.</p

A comparison of experience-dependent locomotory behaviors and biogenic amine neurons in nematode relatives of Caenorhabditis elegans

Background: Survival of an animal depends on its ability to match its responses to environmental conditions. To generate an optimal behavioral output, the nervous system must process sensory information and generate a directed motor output in response to stimuli. The nervous system should also store information about experiences to use in the future. The diverse group of free-living nematodes provides an excellent system to study macro- and microevolution of molecular, morphological and behavioral character states associated with such nervous system function. We asked whether an adaptive behavior would vary among bacterivorous nematodes and whether differences in the neurotransmitter systems known to regulate the behavior in one species would reflect differences seen in the adaptive behavior among those species. Caenorhabditis elegans worms slow in the presence of food; this 'basal' slowing is triggered by dopaminergic mechanosensory neurons that detect bacteria. Starved worms slow more dramatically; this 'enhanced' slowing is regulated by serotonin. Results: We examined seven nematode species with known phylogenetic relationship to C. elegans for locomotory behaviors modulated by food (E. coli), and by the worm's recent history of feeding (being well-fed or starved). We found that locomotory behavior in some species was modulated by food and recent feeding experience in a manner similar to C. elegans, but not all the species tested exhibited these food-modulated behaviors. We also found that some worms had different responses to bacteria other than E. coli. Using histochemical and immunological staining, we found that dopaminergic neurons were very similar among all species. For instance, we saw likely homologs of four bilateral pairs of dopaminergic cephalic and deirid neurons known from C. elegans in all seven species examined. In contrast, there was greater variation in the patterns of serotonergic neurons. The presence of presumptive homologs of dopaminergic and serotonergic neurons in a given species did not correlate with the observed differences in locomotory behaviors. Conclusions: This study demonstrates that behaviors can differ significantly between species that appear morphologically very similar, and therefore it is important to consider factors, such as ecology of a species in the wild, when formulating hypotheses about the adaptive significance of a behavior. Our results suggest that evolutionary changes in locomotory behaviors are less likely to be caused by changes in neurotransmitter expression of neurons. Such changes could be caused either by subtle changes in neural circuitry or in the function of the signal transduction pathways mediating these behaviors

Cool Companions to White Dwarf Stars from the Two Micron All Sky Survey All Sky Data Release

We present the culmination of our near-infrared survey of the optically spectroscopically identified white dwarf stars from the McCook and Sion catalog, conducted using photometric data from the Two Micron All Sky Survey final All Sky Data Release. The color selection technique, which identifies candidate binaries containing a white dwarf and a low-mass stellar (or substellar) companion via their distinctive locus in the near-infrared color-color diagram, is demonstrated to be simple to apply and to yield candidates with a high rate of subsequent confirmation. We recover 105 confirmed binaries, and identify 27 firm candidates (19 of which are new to this work) and 21 tentative candidates (17 of which are new to this work) from the 2MASS data. Only a small number of candidates from our survey have likely companion spectral types later than M5, none of which is an obvious L-type (i.e., potential brown dwarf) companion. Only one previously known white dwarf + brown dwarf binary is detected. This result is discussed in the context of the 2MASS detection limits, as well as other recent observational surveys that suggest a very low rate of formation (or survival) for binary stars with extreme mass ratios

Further Observational Evidence for a Critical Ionising Luminosity in Active Galaxies

We report the results of a survey for HI 21-cm absorption at redshifts of z > 2.6 in a new sample of radio sources with the Green Bank and Giant Metrewave Radio Telescopes. From a total of 25 targets, we report zero detections in the 16 for which optical depth limits could be obtained. Based upon the detection rate for z > 0.1 associated absorption, we would expect approximately four detections. Of the 11 which have previously not been searched, there is sufficient source-frame optical/ultra-violet photometry to determine the ionising photon rate for four. Adding these to the literature, the hypothesis that there is a critical rate of logQ = 56 ionising photons per second is now significant at ~7 sigma. This reaffirms our assertion that searching z > 3 active galaxies for which optical redshifts are available selects sources in which the ultra-violet luminosity is sufficient to ionise all of the neutral gas in the host galaxy.Comment: Accepted by MNRA

Influence of Graduate Speech Language Pathology Student’s Learning Style and Coping Strategies on Training and Development

A hierarchical model using grounded theory analysis was used to investigate clinical development of speech-language pathology graduate students. Eight female students attending a graduate speech-language pathology program participated in interviews prior to beginning graduate training and after each of five subsequent semesters. The interviews were then qualitatively analyzed to create the model of clinical development. This is the first of two companion papers and summarizes two of the five main findings identified. These findings indicated that both stress and the coping strategies used by students influenced clinical abilities and the student’s feelings of self-efficacy throughout graduate training. The results support that learning theory, motivation theory, and understanding of student coping strategies could better promote clinical development and these factors in combination can be used to explain how students progress successfully through a graduate training program. The companion paper describes the remaining three findings that emphasize characteristics associated with the supervision and clinical experiences of graduate students

Femtosecond Spectroscopy with Vacuum Ultraviolet Pulse Pairs

We combine different wavelengths from an intense high-order harmonics source with variable delay at the focus of a split-mirror interferometer to conduct pump-probe experiments on gas-phase molecules. We report measurements of the time resolution (<44 fs) and spatial profiles (4 {\mu}m x 12 {\mu}m) at the focus of the apparatus. We demonstrate the utility of this two-color, high-order-harmonic technique by time resolving molecular hydrogen elimination from C2H4 excited into its absorption band at 161 nm